aml and trisomy 8

Top PDA Devices thumbnail
Sandra R. WolmanFrederick R. AppelbaumMarilyn L. Slovak 1 From Wayne State University, Detroit, MI, and Universities Associated for Research and Education in Pathology (UAREP), Bethesda, MD; the Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center; the Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA, for the Southwest Oncology Group, San Antonio, TX.

; found as a unique additional anomaly in 10%, with other in 25% of CML cases with clonal evolution; these additional anomalies may be present at the diagnosis of CML (in 10%, possibly with unfavourable significance), or may appear during course of the disease, they do not indicate the imminence of a blast crisis, although they also frequently emerge at the time of acute transformation; +8 is more often found in the myeloid than in the lymphoid blast crisis.

  1. BlackBerry

    • . . MDS and AML with trisomy 8 as the sole chromoso... [Am J Hematol. 1997] - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. All Chemicals & Bioassays Resources...All DNA & RNA Resources...All Data & Software Resources...All Domains & Structures Resources...All Genes & Expression Resources...All Genetics & Medicine Resources...All Genomes & Maps Resources...All Homology Resources...All Literature Resources...All Proteins Resources...All Sequence Analysis Resources...All Taxonomy Resources...All Training & Tutorials Resources...All Variation Resources...Generate a file for use with external citation management software.Am J Hematol.

    Google Android

    • doi:10.1038/87158 Kimmo I. Virtaneva 1 , Fred A. Wright 1 , Stephan M. Tanner 1 , Bo Yuan 1 , William J. Lemon 1 , Michael A. Caligiuri 2,  3 , Clara D. Bloomfield 2,  3 , Albert de la Chapelle 1 & Ralf Krahe 1 Acute myeloid leukemia (AML) is a heterogeneous group of diseases. Patients exhibiting normal cytogenetics (AML-CN) constitute the single largest group, and trisomy 8 (AML+8) as the sole abnormality is the most frequent trisomy. How trisomy contributes to tumorigenesis is unknown. Because hematopoietic differentiation is predominantly regulated at the transcriptional level, we proposed that, whatever the underlying molecular leukemogenic event(s) associated with AML-CN and AML+8, the molecular changes at the DNA level should be reflected in specific changes at the RNA level. We used oligonucleotide-based DNA microarrays to study global gene expression in ten AML+8 patients with +8 as the sole chromosomal abnormality and ten AML-CN patients, as well as seven CD34+ cell samples purified from normal bone marrow of healthy individuals as a representative heterogeneous population of stem and progenitor cells.

    iPhone

    • . Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany. E-mail: Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells that alter normal mechanisms of self-renewal, proliferation and differentiation. Non-random clonal chromosome aberrations (i.e., balanced translocations, inversions, deletions, monosomies, and trisomies) are detectable in the leukemic blasts of approximately 55% of adults with AML. These chromosome changes have contributed to the classification of the disease and in the past they have been recognized as the most important prognostic factor for achievement of complete remission, risk of relapse, and overall survival.

Related Searches:

References

Comments

You May Also Like

  • solidworks student design kit 150

    The role of FLT3 in sole trisomy 8 acute myeloid leukemia. - ASCOThe Remember Me feature is an automatic login process which creates a cookie on the hard drive of your computer containing a unique identifier which ASCO.org will utilize to remember you by, thereby avoiding the need to enter username and password upon subsequent visits to ASCO.org.

  • carter high school home page

    . . trisomy 8 | Molecular Pathology Laboratory Network, Inc.2.0 mL (min. 1.0 mL) peripheral blood in sodium heparin preferred, EDTA accepted 1.0 mL (min.

  • african american black business association

    . Objectives The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes.

  • ohio music sent to fail

    Therapy-related CD7+ acute myeloid leukemia with trisomy 8 f... : Anti-Cancer Drugs Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent.

  • a perfect day adventure

    . Impact of trisomy 8 on expression o... [Genes Chromosomes Cancer. 2006] - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function.

  • north carolina realestate at waterford

    Detection of minimal residual disease in an AML pa... [Pathology. 1997] - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. All Chemicals & Bioassays Resources...All DNA & RNA Resources...All Data & Software Resources...All Domains & Structures Resources...All Genes & Expression Resources...All Genetics & Medicine Resources...All Genomes & Maps Resources...All Homology Resources...All Literature Resources...All Proteins Resources...All Sequence Analysis Resources...All Taxonomy Resources...All Training & Tutorials Resources...All Variation Resources...Generate a file for use with external citation management software.

  • rahway exhibit earthly delights

    Patients with isolated trisomy 8 in acute myeloid leukemia are not cured with cytarabine-based chemotherapy: results from Cancer and Leukemia Group B 8461.

  • trail horses for sale quarter horses

    If you have access to this content through a society membership, please first log in to your society website. . If you already have a Wiley Online Library or Wiley InterScience user account: login above and proceed to purchase the article.New Users: Please register, then proceed to purchase the article..

  • mel gibson filmy pl

    Table 1. IDH mutational frequencies in myeloid malignancies comparing 143 patients with isolated trisomy 8 with 64 patients without isolated trisomy 8AML; MPN, myeloproliferative neoplasm.

protecting knees while runningsmall business server return email address

Related Ads

Today in eHow Tech

Featured