; found as a unique additional anomaly in 10%, with other in 25% of CML cases with clonal evolution; these additional anomalies may be present at the diagnosis of CML (in 10%, possibly with unfavourable significance), or may appear during course of the disease, they do not indicate the imminence of a blast crisis, although they also frequently emerge at the time of acute transformation; +8 is more often found in the myeloid than in the lymphoid blast crisis.
doi:10.1038/87158 Kimmo I. Virtaneva 1 , Fred A. Wright 1 , Stephan M. Tanner 1 , Bo Yuan 1 , William J. Lemon 1 , Michael A. Caligiuri 2, 3 , Clara D. Bloomfield 2, 3 , Albert de la Chapelle 1 & Ralf Krahe 1 Acute myeloid leukemia (AML) is a heterogeneous group of diseases. Patients exhibiting normal cytogenetics (AML-CN) constitute the single largest group, and trisomy 8 (AML+8) as the sole abnormality is the most frequent trisomy. How trisomy contributes to tumorigenesis is unknown. Because hematopoietic differentiation is predominantly regulated at the transcriptional level, we proposed that, whatever the underlying molecular leukemogenic event(s) associated with AML-CN and AML+8, the molecular changes at the DNA level should be reflected in specific changes at the RNA level. We used oligonucleotide-based DNA microarrays to study global gene expression in ten AML+8 patients with +8 as the sole chromosomal abnormality and ten AML-CN patients, as well as seven CD34+ cell samples purified from normal bone marrow of healthy individuals as a representative heterogeneous population of stem and progenitor cells.
. Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany. E-mail: Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells that alter normal mechanisms of self-renewal, proliferation and differentiation. Non-random clonal chromosome aberrations (i.e., balanced translocations, inversions, deletions, monosomies, and trisomies) are detectable in the leukemic blasts of approximately 55% of adults with AML. These chromosome changes have contributed to the classification of the disease and in the past they have been recognized as the most important prognostic factor for achievement of complete remission, risk of relapse, and overall survival.
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The role of FLT3 in sole trisomy 8 acute myeloid leukemia. - ASCOThe Remember Me feature is an automatic login process which creates a cookie on the hard drive of your computer containing a unique identifier which ASCO.org will utilize to remember you by, thereby avoiding the need to enter username and password upon subsequent visits to ASCO.org.
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. . trisomy 8 | Molecular Pathology Laboratory Network, Inc.2.0 mL (min. 1.0 mL) peripheral blood in sodium heparin preferred, EDTA accepted 1.0 mL (min.
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. Objectives The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes.
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Therapy-related CD7+ acute myeloid leukemia with trisomy 8 f... : Anti-Cancer Drugs Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent.
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Patients with isolated trisomy 8 in acute myeloid leukemia are not cured with cytarabine-based chemotherapy: results from Cancer and Leukemia Group B 8461.
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Table 1. IDH mutational frequencies in myeloid malignancies comparing 143 patients with isolated trisomy 8 with 64 patients without isolated trisomy 8AML; MPN, myeloproliferative neoplasm.